Click chemistry has already received extensive attention owing to its obvious characteristics，such as readily available starting materials，moderate reaction conditions，high yields and selectivity. Thiol-yne coupling reaction has been recently demonstrated as a novel click reaction，owning to the features of simplicity，high efficiency and versatility，moderate reaction conditions，and a single product. Herein，the definition，characteristics，history as well as applications of click chemistry are reviewed. The mechanism of thiol-yne reaction and the advance in the preparation of functional polymers and surface modification based on this reaction are discussed，including not only synthesis of dendrimers，hyperbranched polymers，networks，functional materials，biomolecules and supramolecules，but also surface modification of materials. The prospects of thiol-yne reaction are also presented.
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